Modulation of DNA structure formation using small molecules

Allosteric modulation of DNA by small molecules.

Many human diseases are caused by dysregulated gene expression. The oversupply of transcription factors may be required for the growth and metastatic behavior of human cancers. Cell permeable small molecules that can be programmed to disrupt transcription factor-DNA interfaces could silence aberrant gene expression pathways. Pyrrole-imidazole polyamides are DNA minor-groove binding molecules th...

INTERACTION OF PROTEINS WITH SMALL MOLECULES

Advances in structure elucidation of small molecules using mass spectrometry

The structural elucidation of small molecules using mass spectrometry plays an important role in modern life sciences and bioanalytical approaches. This review covers different soft and hard ionization techniques and figures of merit for modern mass spectrometers, such as mass resolving power, mass accuracy, isotopic abundance accuracy, accurate mass multiple-stage MS(n) capability, as well as ...

Surveying protein structure and function using bis-arsenical small molecules.

Exploration across the fields of biology, chemical biology, and medicine has led to an increasingly complex, albeit incomplete, view of the interactions that drive life's processes. The ability to monitor and track the movement, activity, and interactions of biomolecules in living cells is an essential part of this investigation. In our laboratory, we have endeavored to develop tools that are c...

Molecular recognition of DNA by small molecules.

Chemists, like artists, are able to construct new threedimensional objects, molecules and materials that exist only in the mind of a person. I became interested in creating novel molecular shapes with properties different from those found in nature shortly after arriving at Caltech in 1973. One cannot design without the brushes and paint of the craft. Indeed, modern organic chemists, standing o...